To acquire an initial list of candidate ICC structures from the Protein Data Bank.
To establish DNA insert sizes for creating output model files of priority candidates in Pymol. These priority candidates will be used in GROMACs simulations.
To successfully use GROMACs software to run molecular dynamic (MD) simulations on co-crystal designs with expanded DNA struts of varying sizes to determine relative stabilities. From these simulations, preferred DNA strut expansion lengths can be established for use in laboratory.
To create educational Pymol videos describing our experimental process.