Here, we will introduce key definitions to help you understand our design.
Scientists have observed that short pieces of double stranded DNA spontaneously order end-to-end (Nakata et. al Science 2007).We can use this interaction to build a biomolecular scaffold.
The starting materials for this project are co-crystals, made of two or more distinct components. We are specifically using co-crystals of DNA-Binding Proteins (DBPs). DBPs are able to bind to single- or double-stranded DNA. We are re-engineering existing co-crystals found in the Protein Data Bank (PDB).
Researchers, such as Yaghi, in the metal organic framework (MOF) community use the term isoreticular to describe when the material is made of a “net” of the same topology. (Zheng et. al, Nature 2009) Our co-crystals are isoreticular as well, since they are built of consistent DNA-protein complexes.
Our design is expected to create a porous and rigid scaffold. Watch our design video to see how this works.
See the Applications section for more information on how we can use our Isoreticular Co-crystals.